03. Aug 2023 | Msonkhano Wachitukuko wa Biopharmaceutical Bioprocess Development

Msonkhano wa 2023 wa chitukuko cha biopharmaceutical bioprocess,radobio amatenga nawo gawo ngati biopharmaceutical cell culture supplier.

Mwachizoloŵezi, biology ya labotale yakhala ikugwira ntchito pang'ono; ziwiya zamtundu wa minofu sizikhala zazikulu kuposa dzanja la woyeserera, kuchuluka kwake kumayesedwa mu "milliliters," ndipo kuyeretsa mapuloteni kumawonedwa ngati kopambana ngati kutulutsa ma micrograms ochepa. Pokhala ndi chidwi chowonjezereka pa kafukufuku womasulira, biology yokhazikika ndi mankhwala obwezeretsanso, asayansi ambiri akuyamba kuyang'ana "chithunzi chachikulu". Kaya akuyesera kuyeretsa ma gramu angapo a mapuloteni kuti ayese crystallization kapena kuyesa kuthekera kopanga mankhwala atsopano a jini kukhala mankhwala atsopano, ofufuzawa posakhalitsa amapeza kuti akuganizira zovuta za chikhalidwe cha maselo akuluakulu.

Chifukwa cha zopambana zamakampani a biotechnology, kufalikira kosunthika kwa chikhalidwe cha ma cell ndi njira yopondedwa bwino. "Munda wayamba kale kuphulika pamene zinthu zambiri zikutuluka, kuchokera ku 100 ml conical flasks zobzalidwa mu shakers mpaka 1,000 L bioreactor chikhalidwe, ndi mankhwala omwe amatha kupangidwa m'maselo a mammalian ambiri.

radobio imatha kupereka zinthu zabwino kwambiri za shaker zama cell kuyimitsidwa, ndipo pamsonkhanowu, chida chatsopano cha shaker CS345X chidawonetsedwa, chomwe chili ndi zabwino izi:
❏ Machulukitsidwe angapo osinthika pazosowa zosiyanasiyana zama cell.
▸ 12.5 / 25 / 50mm chosinthika matalikidwe, munthu akhoza efficiently kukumana zosiyanasiyana zoyesa chikhalidwe cell, popanda kufunika kugula zipangizo angapo pa zosowa zosiyanasiyana kuyesa, kupulumutsa owerenga ndalama zambiri.
❏ Kuthamanga kwakukulu, liwiro lotsika komanso lokhazikika.
▸ Ukadaulo wapadera komanso wotsogola umakulitsa kuchuluka kwa liwiro, komwe kumatha kuzindikira kuthamanga kwa 1 ~ 370rpm, ndikupereka chitsimikizo chokwaniritsa zosowa zosiyanasiyana zoyesera.
❏ Kutsetsereka kwa zitseko zopita m'mwamba kumateteza malo komanso kumapereka mwayi wofikira zikhalidwe.
▸ Kutsetsereka kwa zitseko zopita m'mwamba kumapewa malo okhala ndi chitseko chakunja, komanso kumapangitsa kuti anthu azikhalidwe azifika mosavuta.
❏ Ntchito yoletsa chinyezi yomwe ingasankhidwe imatha kuwongolera chinyezi mpaka 90%rh
▸ Module ya Rindo yokhazikika yowongolera chinyezi imatsimikizira kuwongolera kwachinyezi moyenera komanso kodalirika ndi kukhazikika kwa ± 2% rh
❏ Kuyendetsa maginito kuti igwire ntchito bwino, kugwiritsa ntchito mphamvu zochepa, kuteteza chilengedwe komanso kupulumutsa mphamvu.
▸ Palibe chifukwa chomanga malamba, zomwe zimachepetsa chiopsezo chotenga kachilomboka chifukwa cha kutentha kwapakati chifukwa cha kukangana kwa lamba pa kutentha kwa ma incubation ndi tinthu tating'onoting'ono.